Nick Crombie (Birmingham, England) presents the RePHILL trial, comparing pre-hospital administration of saline with blood products in patients with trauma-related haemorrhagic shock.  Liz Wilcox (Toronto, Canada) delivers an editorial. The session is chaired by Catriona Kelly (Dublin, Ireland).

Derek Russell (Birmingham, USA) and Jon Casey (Nashville, USA) presents the results of the PREPARE II trial, investigating fluid bolus therapy for the prevention of cardiovascular collapse during emergency intubation. Anthony Gordon (London, England) delivers an editorial, which is followed by a panel discussion including Lennie Derde (Utrecht, the Netherlands), Andrew Althouse (Pittsburgh, USA), Elizabeth Wilcox (Toronto, Canada) and Lars Andersen (Aarhous, Denmark). The session is chaired by Chris Seymour from the USA. PREPARE II was simultaneously published in JAMA.

Dr Tine Sylvest Meyhoff (Copenhagen, Denmark) presents the results of the CLASSIC trial at the Critical Care Reviews Meeting 2022. Prof Katryn Maitland (Kalifi, Kenya) delivers an editorial, which is followed by a panel discussion including Prof David Harrison (London, England), Dr Lennie Derde (Utrecht, the Netherlands), Dr Jon Silversides (Belfast, Northern Ireland), and the chief investigator for CLASSIC, Prof Anders Perner (Copenhagen, Denmark). The session is chaired by Prof Bala Venkatesh from Brisbane, Australia.

Drs Padmanabhan Ramnarayan and  Paul Mouncey (both London) present the results of the FIRST-ABC trial, comparing high-flow nasal cannulae therapy with CPAP in acute ill children with respiratory failure, at the Critical Care Reviews Meeting 2022. Dr Srinivas Murthy (Vancouver) delivers an editorial, which is followed by a panel discussion including Profs Kathryn Maitland (Kalifi), John Marshall (Toronto) and Marion Campbell (Aberdeen). The session is chaired by Prof Howard Bauchner.

Rob Mac Sweeney (Belfast, Northern Ireland) hosts a panel discussion including Prof Paul Checchia (Houston, USA), Prof Wes Diddle (Washington DC, USA), Prof Ranjit Lall (Coventry, England), Prof Kathy Rowan (London, England), as well as the NITRIC trial chief investigator Luregn Schlapbach (Zurich, Switzerland) and editorialist Prof Mark Peters (London, England)

Dr Bronwen Connolly asks cheif investigator Luregn Schlapbach questions from the viewers during the livestream of the NITRIC trial results

Prof Mark Peters, from Great Ormond Street Hospital, delivers an editorial on the NITRIC trial, investigating nitric oxide during cardiac surgery for children with congenital cardiac disease. The chief investigator for the trial Assoc Prof Luregn Schlapbach replies.

Assoc Prof Luregn Schlapbach (Zurich, Switzerland) presents the results of the NITRIC trial, investigating nitric oxide during cardiac surgery for children with congenital cardiac disease.

Rob Mac Sweeney hosts a panel discussion on the results of the FIRST ABC trial, comparing HFNO with CPAP in recently extubated children. The panelists are Martha A.Q. Curley (Philadelphia), Christopher M. Horvat (Pittsburgh), Martin Kneyber (Groningen), and David Harrison (London). They are joined by Padmanabhan Ramnarayan (chief investigator), Alvin Richards-Belle (trial manager) and Adrienne Randolph (editorialist).

Chris Nutt (Belfast) asks the chief investigator of the FIRST-ABC trial Padmanabhan Ramnarayan (London) questions from the viewers during the livestream presentation of the trial results.

Adrienne Randolph (Boston) delivers an independent editorial on the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.

Dr Padmanabhan Ramnarayan (London) and Mr Alvin Richards-Belle (London) present the results of the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.

Pär Johansson from Copenhagen joins Rob Mac Sweeney to discuss the fascinating phase II COMBAT-COVID trial, investigating prostacyclin in intubated patients with COVID-19 and severe
endotheliopathy. The trial was published in the American Journal of Respiratory and Critical Care Medicine in November 2021.

Naomi Hammond and Simon Finfer join Rob Mac Sweeney to discuss the reaction of the critical care community to the presentation and publication of both the PLUS trial and the systematic review and meta analysis comparing balanced solutions with 0.9% saline in the critically ill.

Drs Brian Driver and Matt Prekker join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BOUGIE trial, comparing the use of a stylet with that of a bougie in emergency intubation.

Dr Rob Mac Sweeney (Belfast, Northern Ireland) chairs a panel discussion on the results of the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in either the emergency department or the ICU. The panelists are Prof Jonathan Benger (Bristol, England), Dr George Kovacs (Halifax, Canada), Dr Jean-Baptiste (Nantes, France) and Prof Sheila Myatra (Mumbai, India). They are joined by the trialists Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA), Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nashville, USA).

Dr Chris Nutt (Belfast, Northern Ireland) asks questions posed by viewers of the BOUGIE trial results presentation livestream. These are answered by Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA). Prof Jonathan Benger (Bristol, England) also joins the discussion.

Prof Sheila Myatra (Mumbai, India) delivers an independent editorial on the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU. Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA) reply to the editorial and Prof Jonathan Benger (Bristol, England) also joins the discussion.

Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA) and Dr Brian Driver (Minneapolis, USA) present the results of the BOUGIE trial at a Critical Care Reviews Trial Results Livestream, on December 8th, 2021. The BOUGIE trial compared the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU.

Theresa Olasveengen (Oslo, Norway), Victoria Cornelius (London, England) and Christopher Seymour (Pittsburgh, USA) join trialists Mikael Fink Vallentin and Lars Andersen (Aarhus, Denmark), as well as editorialist Gavin Perkins (Coventry, England), to discuss the COCA trial.

Dr Chris Nutt asks Dr Mikael Fink Vallentin and Lars Andersen questions form the viewers, during the livestream presentation of the COCA trial results. The COCA trial investigates calcium for out-of-hospital cardiac arrest and was presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.

Drs Mikael Fink Vallentin and Lars Andersen (University of Aarhus, Denmark) present the results of the COCA trial, investigating calcium for out-of-hospital cardiac arrest. The COCA trial results were presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.

Prof Gavin Perkins (University of Warwick) delivers an editorial on the COCA trial, investigating calcium for out-of-hospital cardiac arrest. The COCA trial results were presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.

Dr Bharath Kumar presents preliminary results of the HOPE trial and discusses the difficulties of undertaking research during a pandemic.

Bram Rochwerg (Hamilton, Canada), Paul Mouncey (London, England) & Colin McArthur (Auckland, New Zealand) join trialists Sheila Nainan Myatra (Mumbai, India), Bala Ventakesh (Brisbane, Australia) and Anders Perner (Copenhagen, Denmark), as well as editorialists Marion Campbell (Aberdeen, Scotland), to discuss the COVID STEROID 2 trial.