Prof Jorrit Lemkes (Amsterdam, The Netherlands) presents the COACT Trial, investigating the timing of coronary angiography in patients with cardiac arrest without ST elevation. This is followed by an editorial by Dr Chris Nickson (Melbourne, Australia). This talk was given at the Critical Care Reviews Meeting 2020, in Titanic Belfast.

Dr Paul Young describes MEGA-ROX, a registry-based, adaptive platform trial investigating oxygenation targets in the critically ill. This is followed by a panel discussion involving trialists, methodologists and statisticians on this ambitious trial design.

Dr Paul Young (Wellington, New Zealand) presents the ICU-ROX trial, investigating conservative oxygen therapy in mechanically ventilated patients in the ICU, at the Critical Care Reviews Meeting 2020, in Titanic Belfast. Prof Anders Perner (Copenhagen, Denmark) gives an editorial on this trial afterwards.

Prof Kathryn Maitland delivers the honorary John Hinds Lecture, entitled "A Higher Calling: two decades of emergency research in Africa", at the Critical Care Reviews Meeting 2020, at Titanic Belfast.

Prof Kathryn Maitland discusses the TRACT trial, investigating red blood cell transfusion in African children with anaemia, at the Critical Care Reviews Meeting 2020, at Titanic Belfast.