Prof Alistair Nichol (Dublin & Melbourne) discusses why the REMAP-CAP adaptive platform trial has chosen to investigate ivermectin, given the controversy surrounding this agent.
Dr Lennie Derde is the Trial Steering Committee Chair and the European Coordinating Investigator for the REMAP-CAP project. She discusses the running of the REMAP-CAP trial, her background in critical care and infectious diseases, how she got into critical care research, the background of the REMAP-CAP trial and its current workload for her. We also review the output from the trial to date and finish by considering how this pandemic is likely to progress.
BaSICS trial leads Drs Fernando Zampieri & Alexandre Biasi Cavalcante join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BaSICS trial results.
Niklas Nielsen, the chief investigator for the TTM2 trial, joins Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the TTM2 trial results.
Prof Manu Shankar-Hari, the lead for the WHO REACT group's prospective meta analysis on interleukin 6 antagonism in patients hospitalised with COVID-19, joins Rob Mac Sweeney to discuss this important work
Prof Giuseppe Citerio (Milan) joins Rob Mac Sweeney to discuss the global SYNAPSE-ICU study, investigating the use of intracranial pressure monitoring in acute brain injury.
Phil Gillen (Belfast) asks questions posed by the viewers of the TTM2 results livestream to the TTM2 trialists Niklas Nielsen, Josef Dankiewicz and Gisela Lilja.
Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund) presents the results of the landmark TTM2 trial, comparing hypothermia (33°) with normothermia (<37.8°) in 1850 comatose survivors of out-of-hospital cardiac arrest.
Panellists Jerry Nolan, Kathy Rowan and Terri Hough join editorialist Stephen Bernard and TTM2 investigators Niklas Nielsen, Josef Dankiewicz and Gisela Lilja to discuss the landmark TTM2 trial at the Critical Care Reviews hosted TTM2 results livestream.
Prof Stephen Bernard (Melbourne) delivers an editorial on the TTM2 trial result, delivered as part of the Critical Care Reviews hosted TTM2 Trial Results Livestream.
Prof Derek Angus, from Pittsburgh, USA, discusses a modern healthcare system which merges research into clinical practice, producing a "learning while doing" healthcare model.
Professor Kath Maitland joins Rob Mac Sweeney to discuss the COAST trial, investigating oxygen therapy in African children with severe pneumonia.
In the latest episode on the REMAP-CAP series, Prof Alistair Nichol (Dublin / Melbourne) discuss the upcoming ventilation domain with Rob Mac Sweeney.
Professors Vincenzo Russotto and Sheila Myatra join Rob Mac Sweeney to discuss their INTUBE study, investigating tracheal intubation practices in the critically ill around the world.
Mathias Pletz discusses pandemics and the role of REMAP-CAP adaptive platform trial in responding to the COVID-19 pandemic
John Marshall and Srinivas Murthy discuss the choice of interventions in the REMAP-CAP adaptive platform trial
Scott Berry discusses the methodological and statistical framework behind the REMAP-CAP trial
Prof Steve Webb, from Perth, Australia, discusses the origin, design and execution of the REMAP-CAP adaptive platform trial
Prof Derek Angus and Prof Anthony Gordon, senior investigators for the REMAP-CAP trial, discuss the COVID-19 steroid domain results of the REMAP-CAP trial on the Critical Care Reviews Podcast
Prof Jorrit Lemkes (Amsterdam, The Netherlands) presents the COACT Trial, investigating the timing of coronary angiography in patients with cardiac arrest without ST elevation. This is followed by an editorial by Dr Chris Nickson (Melbourne, Australia). This talk was given at the Critical Care Reviews Meeting 2020, in Titanic Belfast.
Dr Paul Young describes MEGA-ROX, a registry-based, adaptive platform trial investigating oxygenation targets in the critically ill. This is followed by a panel discussion involving trialists, methodologists and statisticians on this ambitious trial design.
Dr Paul Young (Wellington, New Zealand) presents the ICU-ROX trial, investigating conservative oxygen therapy in mechanically ventilated patients in the ICU, at the Critical Care Reviews Meeting 2020, in Titanic Belfast. Prof Anders Perner (Copenhagen, Denmark) gives an editorial on this trial afterwards.
Prof Kathryn Maitland delivers the honorary John Hinds Lecture, entitled "A Higher Calling: two decades of emergency research in Africa", at the Critical Care Reviews Meeting 2020, at Titanic Belfast.
Prof Kathryn Maitland discusses the TRACT trial, investigating red blood cell transfusion in African children with anaemia, at the Critical Care Reviews Meeting 2020, at Titanic Belfast.