Lars Andersen (Aarhus, Denmark) presents the VAM-IHCA trial on June 15th at the Critical Care Reviews Meeting 2022, in Titanic Belfast. The VAM-IHCA trial investigates the combination of vasopressin and methylprednisolone in in-hospital cardiac arrest. Chris Seymour (Pittsburgh, USA) delivers an editorial after the trial presentation. The session is chaired by Catriona Kelly (Dublin, Ireland).