John Myburgh and Ian Seppelt  (Sydney) present the results of the SuDDICU trial at the Critical Care Reviews Meeting 2022, in Titanic Belfast. SuDDICU investigates selective digestive decontamination in critically ill mechanically ventilated patients. Naomi Hammond (Sydney) follows with a presentation of a systematic review and meta analysis also on SDD. John Marshall (Toronto) delivers an editorial. Danny McAuley (Belfast), Bodil Steen Rasmussen (Aalborg) and Victoria Cornelius (London) join the presenters for a panel discussion. The session is chaired by Chris Seymour (Pittsburgh).

Matthew Semler presents the results of the PILOT trial, comparing low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Paul Young delivers an editorial and Chris Nutt asks questions from the viewers. The expert panel discussion includes Victoria Cornelius, Angelique de Man, Bodil Steen Rasmussen and Gilles Capellier. The paper was simultaneously published in the New England Journal of Medicine.

Prof Jan Belohlavek (Prague, Czech Republic) presents the Prague Out-of-Hospital Cardiac Arrest Study at the Critical care Reviews Meeting 2022. This study investigates the efficacy of an eCPR programme in patients with refractory out-of-hospital cardiac arrest. Dr Liz Wilcox (Toronto, Canada) follows with an editorial on the trial.