Rob Mac Sweeney hosts a panel discussion on the results of the FIRST ABC trial, comparing HFNO with CPAP in recently extubated children. The panelists are Martha A.Q. Curley (Philadelphia), Christopher M. Horvat (Pittsburgh), Martin Kneyber (Groningen), and David Harrison (London). They are joined by Padmanabhan Ramnarayan (chief investigator), Alvin Richards-Belle (trial manager) and Adrienne Randolph (editorialist).

Chris Nutt (Belfast) asks the chief investigator of the FIRST-ABC trial Padmanabhan Ramnarayan (London) questions from the viewers during the livestream presentation of the trial results.

Adrienne Randolph (Boston) delivers an independent editorial on the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.

Dr Padmanabhan Ramnarayan (London) and Mr Alvin Richards-Belle (London) present the results of the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.

Pär Johansson from Copenhagen joins Rob Mac Sweeney to discuss the fascinating phase II COMBAT-COVID trial, investigating prostacyclin in intubated patients with COVID-19 and severe
endotheliopathy. The trial was published in the American Journal of Respiratory and Critical Care Medicine in November 2021.

Naomi Hammond and Simon Finfer join Rob Mac Sweeney to discuss the reaction of the critical care community to the presentation and publication of both the PLUS trial and the systematic review and meta analysis comparing balanced solutions with 0.9% saline in the critically ill.

Drs Brian Driver and Matt Prekker join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BOUGIE trial, comparing the use of a stylet with that of a bougie in emergency intubation.